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Daptomycin is an antibiotic that is known to have rhabdomyolysis as a significant side effect. Rhabdomyolysis is a condition characterized by the breakdown of muscle tissue, which leads to the release of muscle fiber contents into the bloodstream. This condition can result in elevated levels of creatine kinase (CK) and can potentially lead to complications such as acute kidney injury due to the increased myoglobin levels from muscle breakdown.

In the case of daptomycin, the risk of rhabdomyolysis increases, particularly when it is used in higher doses or over extended periods. Therefore, monitoring of muscle enzymes, particularly CK, is recommended during treatment with daptomycin, especially in patients who may be at increased risk for muscle injury or in conjunction with other medications known to affect muscle tissue.

The other options are less commonly associated with daptomycin. Although hypotension can occur in various medical scenarios, it’s not a known side effect specifically linked to daptomycin. Renal failure can occur with many medications, especially those that are nephrotoxic, but it is not a direct side effect of this drug per se. Anemia is a general term for a decreased red blood cell count